• Ethanolic extract of Hyssopus officinalis moderates blood parametric (glucose, total cholesterol and triglycerides) in alloxan-induced diabetic rats
  • Masumeh Salem,1,*
    1. Student research Center, Baharestan 1 Education Office, Baharestan 1, Tehran, Iran


  • Introduction: Background and aim: Diabetes mellitus results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Subsequent lack of insulin leads to increased blood and urine glucose. Hyssopus officinalis is a medicinal plant which had been has various used in traditional medicine. Traditionally, this medicinal plant used for treatment of asthma, fever, epilepsy and has have anti-depressant effect. In addition, recent studied revealed that this plant has antioxidant effect. In the current study, the effect of ethanolic extract of Hyssopus officinalis on the levels of blood glucose, total cholesterol and triglycerides in normal and alloxan-induced diabetic rats were evaluated.
  • Methods: Materials and methods: The effect of intra-peritoneal administration of ethanolic extract of Hyssopus officinalis (5, 10 and 20 mg/kg) for 15 days consequently on the level of serum glucose, total cholesterol and triglycerides in normal and alloxon-induced diabetic rats were evaluated.
  • Results: Results: Intra-peritoneal administrations of Hyssopus officinalis extract significantly decreased blood glucose, total cholesterol and triglycerides in diabetic rats but not in normal rats. The administration of Hyssopus officinalis extract did not change the serum parameters in normal rats. A comparison was made between the action of Hyssopus officinalis extract and glibenclamide (20 mg/kg), the known antidiabetic drug. The antidiabetic effect of the extract was the same of that observed with glibenclamide.
  • Conclusion: These finding revealed that this plant has hypoglycemic and hypolipidemic activities. It is concluded that this plant can be considered as excellent candidate for future studies on diabetes mellitus.
  • Keywords: Hyssopus officinalis, diabetes, glucose, total cholesterol, triglycerides