Regenerate and repair of the skin by using of the hair follicle stem cells
Regenerate and repair of the skin by using of the hair follicle stem cells
Maryam Alizadeh,1,*
1. Student research Center, Baharestan 1 Education Office, Baharestan 1, Tehran, Iran
Introduction: Nowadays, the use of new therapies such as cell therapy has opened a new window for the treatment of the diseases. In cell therapy, embryonic and adult stem cells are used. Adult stem cells are present in several parts of the adult body, including the bone marrow and the adipose tissue. One of the tissues that has stem cells is the bulge area of the hair follicle. The hair follicle has a repository of stem cells that play a key role in the growth, repair and differentiation of the hair follicles. If the lower third of the follicle is cut off, the rest of the follicle can be repaired to make a new hair. Here, new epidermal cells originate from the bulge. In this study, skin regeneration and repair using hair follicle stem cells were investigated.
Methods: First, these cells must be properly directed to the keratinocyte line. The selection and purification of differentiated keratinocyte precursors is then performed by cell surface markers labeled with specific antibodies. In the next step, cytokines and external growth factors are used as a complement to the culture medium and final differentiation factors.
Results: In fact, the hair follicle is a viable option for adult stem cells due to its easy access and high-capacity differentiation potential. And if the above steps are done correctly, the hair follicle stem cells will differentiate into skin epithelial cells.
Conclusion: The use of hair follicle stem cells is a good option for the treatment of skin lesions and presents a bright future for the treatment of skin lesions before doctors and researchers.