Evaluation of antibacterial function of liposomes containing aloe vera extract by Mozaffari method
Evaluation of antibacterial function of liposomes containing aloe vera extract by Mozaffari method
Maryam Cheshmberah,1Mohammad Javad Forouzani-Moghaddam,2,*
1. MSc of Genetic, Sistan & Balochestan university, Zahedan, Iran 2. Msc of Food Microbiology, School of Paramedical, Iran University of Medical Sciences, Tehran, Iran
Introduction: The aim of this study was to investigate the antibacterial function of liposomes containing aloe vera extract. For this purpose, liposomes containing aloe vera extract have been synthesized for optimal use against Staphylococcus aureus and Escherichia coli.
Methods: The type of study is laboratory research. The nanoparticle synthesis method is Mozaffari method. Particle characterization has been performed in terms of size and charge with a DLS device and morphology with an atomic energy microscope (AFM) and the amount of loading and release with a spectrophotometer. MIC tests were then performed to evaluate the performance of nanoparticles containing aloe vera extract on Staphylococcus aureus and Escherichia coli.
Results: The mean particle diameter was 72 nm and its zeta potential was 14 mV. The loading rate in nanoparticles was 60%, which was calculated by reading the absorption of light from the standard Zanian curve. The minimum inhibitory concentration (MIC) of Staphylococcus aureus and Escherichia coli for nanoparticles was 62.5 and 125 mg / ml.
Conclusion: Nanoparticles containing aloe vera extract kill the bacterial bacteria Staphylococcus aureus and Escherichia coli and can be used as antibacterial nanosystems.