miR-492: A novel potential therapeutic target an prognostic factor in cancers
miR-492: A novel potential therapeutic target an prognostic factor in cancers
Anita Alizadeh,1,*
1. M.SC. student of Genetics, Department of Biology, Higher Education Institute of Rab-Rashid, Tabriz, Iran
Introduction: microRNAs (miRNAs) are a class of small non coding RNAs with approximately 22 nucleotides in length and have ability to regulate gene expression in post transcriptional level. miRNAs as highly conserved non coding RNAs have crucial functions in different biological processes of human cancers. Moreover, they can be regulated by circular RNAs (circRNAs). Furthermore, stability of miRNAs in body fluids and their tumor specific expression have introduced them as valuable candidates for early detection and effective treatments of cancer. miR-492 which is located at chromosomal position 12q22 which has been demonstrated to be dysregulated in various types of human cancers.
Methods: The present study was conducted in a review of the digital and library resources also authentic scientific sources of the PubMed site and google scholar with the key word of mir-492 in cancer with aim to study interactions between miR-492 and other target genes and signaling pathways which involved in tumorigenesis of cancer.
Results: Studies have shown that miR-492 is upregulated in various types of cancer such as gastric, prostate, ovarian, breast, bladder, cervical, colon, endometrial, hepatoblastoma and retinoblastoma. miR-492 acts as an oncogene in these cancers and plays an important role in tumorigenesis by affecting cell proliferation, invasion, migration, epithelial to mesenchymal transition (EMT) and apoptosis which exerts these regulatory effects by interfering with various circRNAs such as circTET1 and circ-0001368 and signaling pathways including wnt/βcatenin and PI3K/AKT, PTEN pathways.
Conclusion: Given that, this review summarizes the related research of miR-492 as the multifunctional miRNA in various cancer development and tumorigenesis. Accordingly, miR-492 may acts as a novel potential biomarker for cancer diagnosis or treatment in future.