• Investigation of the effect of Na + and H + converters on sperm motility in humans
  • Ali Ahmadi,1,*
    1. Student, Faculty of Biological Sciences and Technologies, Islamic Azad University Sari Branch, Sari, Iran


  • Introduction: Introduction: Up to 15% of human couples are infertile and infertility in men is almost half of these cases. reach. Mammalian flagellum is a special type of motor fluid that is needed for sperm motility and male fertility. The effective movement of the flagellum depends on the axonal function, which in turn depends on the appropriate ion homeostasis in the flagellum chamber. The aim of this study was to investigate the effect of Na + and H + converters on sperm motility in humans
  • Methods: Methods: This study was conducted in 1399 by searching for keywords such as Na +, H + converters and sperm motility in humans in reputable databases such as: pub med and google scholar. Finally, 15 articles were found from These 15 articles used 10 articles
  • Results: Results: Based on the studies obtained from the articles, the results show that physiologically, sperm is of great importance in terms of motility, maturity and acrosome reaction, which maintains the pH of sperm through the involvement of several mechanisms among them with sodium-hydrogen converters. . They are also integrated membrane proteins that exchange sodium + hydrogen. All of these physiological processes are possible due to the micro-orchestrated signaling pathways between skeletal protein complexes and plasma membrane elements, such as ion channels and carriers. Disruption or regulation of these proteins can lead to ciliary motility impairment. In this study, we reviewed recent advances in ion channel function and transport and related signaling pathways in human sperm parasites. Pathological and pharmacological studies of specific ion channels of sperm in species that can (For example, empty mice) provide clear evidence of the role of the canal in sperm physiology and ultimate fertilization. In this study, sodium-hydrogen exchangers were shown to be essential for sperm function because They cause infertility due to severe defects in sperm motility
  • Conclusion: Conclusion: According to the findings, it is better to set up a program to reduce risk that the risk factor is not dangerous for us and it is recommended that we continue to do a good job of this study.
  • Keywords: Na +, H + converters and sperm motility in humans