Introduction: Numerous factors can affect male fertility, Reproductive toxicity is a major challenge associated with aluminum (Al) exposure which in the last 3 years, has published many articles in databases. High utilization of Al-containing products will increase the concentration of this metallic element in the consumers’ organs and damage their various tissues (including the testicular tissues of humans and animals). Therefore, the present review study was conducted to determine the role of the protective effect of some Antioxidants substances on male fertility.
Methods: In this study, PUB MED / SCOPUS databases from 2017 to 2020 were searched for related articles. In this systematic review, we intend to analyze and evaluate greater than ten powerful elements in growing the fertility of men who've been exposed to Al, such as Curcumin, Tyrosol , esculetin , Melatonin , L-arginine,vitamin E, vitamin E-selenium combination, Propolis , Piper Guineans, pomegranate liquid.
Aluminum (Al), the third most common element in the Earth's crust, has significant toxic potential for humans. Although Al toxicity was initially recognized as a neurological, in recent years the destructive effects of Al on reproductive tissues and their function have received more attention. Moreover, high levels of Al in spermatozoa and seminal plasma of humans have been reported to reduce sperm viability and motility Al may cause male reproductive toxicity through various mechanisms such as inducing oxidative stress, interfering with spermatogenesis and steroidogenesis, impairing cell signaling, disrupting the blood-testis barrier, and affecting the endocrine system
Antioxidants (AO) are compounds that prevent oxidation. In the tissue, they interrupt oxidative chain reactions.In recent years, increasing attention has been paid to the use of nutritional antioxidants (such as plant products) in diseases related to oxidative stress. The protective effects of natural products have been attributed to their role in eliminating free radicals and antioxidant defense regulators.
As a free radical scavenger, these substances can greatly inhibit the production of reactive oxygen species (ROS) both in vitro and in vivo. It also has anti-cancer, anti-inflammatory and anti-bacterial properties
But their most important effect is to reduce testicular tissue apoptosis by reducing oxidative stress as well as increasing sperm motility and quality.
Results: considerable reductions in body and testis weight; plasma testosterone and luteinizing hormone levels; sperm count, motility, morphology, and viability; germinal epithelium thickness; seminiferous tubules diameter; as well as, superoxide dismutase activity were observed in rats exposured with Al.
antioxidants treatment significantly improved morphological normality and sperm count, motility, and viability in rats receiving Al chloride. . but ,No significant differences in gonadotrophin (FSH) levels and nuclear diameter of spermatogonia were detected among all groups.
Conclusion: in rats receiving antioxidants(AO) considerably reversed the adverse effects of Al on testicle gland and spermatozoon quality, In other words, AO may counteract the negative effects of Al within the mentioned- reproductive parameters.