Evaluation of the effect of probiotics in the prevention and treatment of gastrointestinal diseases
Evaluation of the effect of probiotics in the prevention and treatment of gastrointestinal diseases
Mohammad Javad Forouzani-Moghaddam,1,*
1. Msc of Food Microbiology, School of Paramedical, Iran University of Medical Sciences, Tehran, Iran
Introduction: Probiotics are living microorganisms that have beneficial effects on gastrointestinal health. Probiotics do this by modulating the gut microbial flora. The aim of this study was to review the available clinical evidence on the effects of probiotics in the prevention and treatment of gastrointestinal diseases during the years 1995-2020.
Methods: Articles related to the subject were searched in PubMed and Science direct websites and clinical trials and systematic review articles examining the effects of probiotics in the prevention and treatment of gastrointestinal diseases were included in the study.
Results: There is currently good evidence for the therapeutic effects of probiotics on infectious diarrhea, antibiotic-induced diarrhea and lactose intolerance. Evidence has also been found on the beneficial effects of probiotics in the treatment of inflammatory bowel disease, irritable bowel syndrome, constipation, Helicobacter pylori infection, and the prevention of colon cancer. Different probiotic bacteria it is difficult to make a definite statement about the results of these studies. Further clinical studies are necessary to determine the effective dose and dose of probiotics in various diseases.
Conclusion: Probiotics can be used as adjunctive therapy in gastrointestinal diseases, but the need for further studies and appropriate design to clarify the efficacy and safety of probiotics in the prevention and treatment of gastrointestinal diseases and their mechanism of action.