Introduction: This study aimed to evaluate the mRNA levels of MEF2C in tumor and adjacent non tumor tissues of 70 (younger and older than 40 years) women with invasive ductal carcinoma as well as three breast cancer cell lines. The association of MEF2C expression and the clinical characteristics of patients have also been investigated.
Methods: MEF2C mRNA levels were studied by Real time PCR and data were analyzed by T-test and ANOVA.
Results: Low levels of MEF2C mRNA were observed in tumor tissues compared with adjacent non tumor tissues (P<0.001). In addition, the results show that patients with large tumors and positive lymph node metastasis have low levels of MEF2C mRNA (P<0.05).
Conclusion: The low mRNA levels of MEF2C in breast cancer patients possibly associated with lymph node metastasis and larger tumor size.