Investigating the relation between the role of HPV and cervical cancer incidence
Investigating the relation between the role of HPV and cervical cancer incidence
Nazanin ghasemi varaki,1,*Touraj Rahimi,2
1. cellular and molecular biology department science faculty 2. Agricultural biotechnology plant production andh- genetics dept.agriculture faculty.shahre Qods branch -Islamic Azad University-Tehran-Iran
Introduction: Cervical cancer is the fourth leading cause of cancer and one of the main causes of death in women all around the world. Approximately 70% of cervical cancers occur in developing countries. Cervical cancer screening programs in developing countries have greatly reduced the incidence of the disease. Cervical cancer is a type of cancer that originates from cervical cells. Several factors involved in the development of cervical cancer, but in 90% of cases, human papillomavirus is the cause. HPV consists of a family of small, double-stranded DNA viruses that infect the epithelium. The aim of this review study is to investigate the possible association between the role of HPV in the development of cervical cancer.
Methods: The present study is based on scientific reports on the association of HPV virus in the incidence of cervical cancer, which was analyzed by searching and summarizing the results in scientific databases such as Science Direct, Springer, Google Scholar, and PubMed.
Results: The results of several studies have shown that most of the people infected by HPV virus, do not develop cancer cells. And a weak immune system is a risk factor for cervical cancer due to this virus. Evidence has shown that 90% of cervical cancers are associated with squamous cell carcinoma and 10% are associated with adenocarcinoma and other cases. The degree to which HPV virus can cause cancer depends on its types that infect cervical cells, causing epigenetic changes and developing precancerous cells. Studies have shown that two different types of HPV can infect the genital areas: low risk HPV types HPV6 and HPV11 are the cause of benign warts and usually improve. And high-risk HPV types 45,33,31,18,16 are associated with genital cancer. The results have shown that cervical cancers with HPV16 were more common (99%).
Conclusion: In conclusion, according to the World Health Organization and the high incidence of cervical and genital cancers caused by HPV, show the importance of prevention principles and effective vaccinates in certain ages to control and prevent human papillomavirus.