• Investigation of the effect of bicarbonate (HCO3-) signals on sperm flagellum movement in humans
  • Ali Ahmadi,1,*
    1. Student, Faculty of Biological Sciences and Technologies, Islamic Azad University, Sari, Iran


  • Introduction: Mammalian flagellum is a special type of motor fluid that is required for sperm motility and male fertility. The effective movement of the flagellum depends on axonal function, which in turn depends on the appropriate ion homeostasis in the flagellum chamber. All of these physiological processes are also possible due to the micro-orchestrated signaling pathways between skeletal protein complexes and plasma membrane elements, such as ion channels and carriers. The aim of this study was to investigate the effect of bicarbonate (HCO3-) signals on sperm flagella in humans.
  • Methods: This study was conducted in 2021 by searching for keywords such as bicarbonate signal, sperm flagellum and sperm motility in valid databases such as: pub med and google scholar, which finally found 15 articles, of which 15 articles 10 articles were used
  • Results: Based on studies from articles, the results show that HCO3- is a key factor in regulating sperm motility. High concentrations of HCO3- in the female reproductive system increase the frequency of sperm, which promotes sperm through the female reproductive system. Carbonic anhydrides (CA), which catalyze the reversible hydration of CO2 to HCO3-, are potential candidates for regulating HCO3- homeostasis in sperm and the composition of the male and female reproductive fluids. Provides a high concentration of bicarbonate High concentrations of bicarbonate are very important for the capacitor. In particular, HCO3- is present directly in bicarbonate-dependent solution, which activates bicarbonate-dependent solution cyclase. Quotes work to provide a stable setting of Cl− transitions. In the epididymis, including the cap, body, and caoid epididymis, low bicarbonate concentrations and acidic pH of the lumen are important for maturation, storage, and fertility of sperm. , Which makes significant changes along the epididymal duct. Several channels and ion transport, such as cystic fibrosis transmission conduction regulator, bicarbonate converter have been proposed for the production of liquid compounds with low acidic HCO3- concentrations.
  • Conclusion: According to the findings, it is better to set up a program to reduce risk that the risk factor is not dangerous for us and it is recommended that we continue to do a good job of this study.
  • Keywords: Bicarbonate signal, sperm flagella and sperm motility