Effect of Physical Activity on gene expression in cancer

Effect of Physical Activity on gene expression in cancer
farzaneh Teimouri,¹ Ali Mohammad Ahadi,² Zahra Zamanzadeh ,^3,*
1. Department of Biotechnology Faculty of Biological Sciences and Technology Shahid Ashrafi Esfahani University, Isfahan, Iran.
2. Associate Professor, Department of Genetic, Faculty of Science, Shahrekord University. Shahrekord, Iran.
3. Department of Biotechnology Faculty of Biological Sciences and Technology Shahid Ashrafi Esfahani University, Isfahan, Iran
Introduction: There are significant epidemiological evidences that regular physical activity or exercise reduce the risk of developing diseases such as cardiovascular disease , diabetes and some types of cancers. Exercise also affects the function of our genes such as increases of methylation. Gene expression studies may be a sensitive tool to characterize the early effects of exercise on immune regulation.
Methods: To review the effect of Physical Activity on gene expression in cancer we conducted a bibliography research using sources from PubMed, and websites of institutions like Cancer Research the WHO.
Results: Moderate exercise can exert a number of effects on the body such as improving insulin sensitivity in addition to lowering blood pressure. Vigorous exercise causes damage to the muscle resulting in disarrangement in fiber structures, loss of fiber integrity, and secretion of muscle protein. There are several hypothesized biological mechanisms involved in the association between physical activity and cancer risk, including an effect on adiposity, endogenous sex and metabolic hormones, chronic inflammation, oxidative stress, and genomic instability . Then it is increase or decrease the risk of cancer.
Conclusion: Therefor changes in Physical Activity have a high impact on reducing the signaling pathways thus ,it is reducing the risk of cancer.
Keywords: Physical activity . Moderate exercise . Vigorous exercise. Gene expression . Inflammation .cancer.