The effect of IL-6 gene expression on diabetes-related depression in patient for diabetes type 2

The effect of IL-6 gene expression on diabetes-related depression in patient for diabetes type 2
elahe aliheydari,^1,* mahsa mohammad amoli,² enayatallahyazdanpanah@yahoo.com,³ mahdi pirhoseinloo,⁴
1. 1. Department of Basic Sciences, Payam Noor University, Iran
2. Endocrinology and metabolism research center, Tehran university of medical sciences, Tehran, Iran
3. Department of Basic Sciences, Payam Noor University, Iran
Introduction: 2-type Diabetes is a Metabolic Disorder which Cause Hyperglycemia. Increased inflammatory cytokines Such as IL-6 can be associated with incidence of depression and type -2 Diabetes. Therefore, the above study investigated the effect of IL-6 gene expression on diabetes-related depression in patients with type 2 diabetes.
Methods: This study was performed on 50 patients with type 2 diabetes mellitus with depression and 50 patients type 2 diabetes without depression as control group. RNA extraction from Blood was performed by Yekta tajhiz kit and finally Gene expression assay was performed quantitatively using Real Time RTPCR and Nano drop.
Results: Interleukin 6 gene expression decreased in patients with type 2 diabetes with depression compared to those with type 2 diabetes without depression, which is not statistically significant.
Conclusion: The present study showed that decreased levels of interleukin-6 gene expression are not associated with post-diabetes depression. Therefore, more research is needed in this Field.
Keywords: Gene Expression - IL-6 - Diabetes Type 2 - Depression