Investigation of probiotics on neonatal colic

Investigation of probiotics on neonatal colic
Masoumeh Shafiean,^1,* Maryam Salimi,² Mahtab Agaee Jaghargh,³ Elahe Safari,⁴
1. Midwifery student, School of nursing,Midwifery and Medicine Islamic Azad University,Mashhad,Iran
2. Midwifery student, School of nursing,Midwifery and Medicine Islamic Azad University,Mashhad,Iran
3. Midwifery student, School of nursing,Midwifery and Medicine Islamic Azad University,Mashhad,Iran
4. Nursing student, School of nursing,Midwifery and Medicine Islamic Azad University,Mashhad,Iran
Introduction: Infantile colic describes excessive crying of unknown cause in otherwise well infants. Above 63%, of pediatricians surveyed, believed that the colic prevalence rate was >40% in the Middle East and North Africa region, which is greater than the 20% rate reported in worldwide surveys .Colic is traditionally defined by the Wessel’s criteria of crying or fussing more than three hours of the day for more than three days of the week. A number of psychological, behavioural and biological components (food hypersensitivity, allergy or both; gut microflora and dysmotility ) are thought to contribute to its manifestation . The aim of this systematic review is evaluates the efficacy and safety of prophylactic probiotics in preventing or reducing severity of infantile colic.
Methods: We found 24 clinical trial and Randomized Controlled Trial articles by searching in pubmed, Embase, Cochrane and SID from 2015 until 2019. The keywords were : neonatal colic, infant colic, probiotics, lactobacillus. 8 articles were excluded by checking their title, 3 articles were excluded by checking their abstracts and 2 articles were excluded by checking their full text. Finally , there were 11 articles related to our title and keywords.
Results: Finally,10 articles were included in the study. Six studies examined Lactobacillus reuteri DSM , one examined Lactobacillus rhamnosus(7), one examined Probiotic-Mixture. one studies began probiotics during pregnancy and continued administering them to the baby after birth . At another study one group received a sachet of probiotics per day along with a conventional treatment for two consecutive weeks. All studies were blinded, and at low risk of attrition and reporting bias. These Articles show that with the use of probiotics, the crying time is significantly reduced (68.4 min/day vs. 98.7 min/day; p = 0.001). According to the results of one examined Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus , there was no significant difference between probiotic and control groups.
Conclusion: Evidence suggests that probiotics have a positive effect on neonatal colic. But more studies are needed to give a definitive opinion like examine other type of probiotics.
Keywords: neonatal colic, infant colic, probiotics, lactobacillus