• The Inhibitory Effect of Let7 on Metastasis of Breast Cancer Cells
  • Azin Khodadust,1,* Pinar safari,2
    1. Faculty of Paramedicine , tabriz University of Medical sciences, Tabriz, Iran
    2. رجائي شهر ميدان رسالت ک وحدت پ7 ط3


  • Introduction: MicroRNAs(the group of small RNAs with 19-25 neucloids) are one of the largest classes of post-transcriptional regulators which designate a small portion of the genome. They control gene expression in different biological processes, and it has been proved that microRNAs are also associated with cell cycle regulation, metastasis, apoptosis, etc. Second, microRNA to be found was the one named Let7 in year 2000.Metastasis is the action in which cancer cells migrate through the body and start to grow in distant new locations, and breast cancer is a type of cancer that develops from breast tissue in which growth and division of some breast cells are much faster than normal ones.
  • Methods: This article is a review article in which the total investigation, included 26 articles located in databases including Web of Science, PubMed, and Google Scholar ( P value < 0.005)
  • Results: As microRNAs play a precise role in carcinogenesis, studying changes in microRNA expression in cancers and other human malignancies is critical. It is evidenced that Let7 cluster is mostly downregulated in tumors of the breast and also lungs and thyroid; therefore, increasing levels of Let7 can have an inhibitory effect on metastatic tumors like breast cancer cells.
  • Conclusion: In order to upgrade the survival of cancer patients, it is essential to improve treatment of metastasis because it has been the main cause of cancer mortality for years. Huge potential of microRNAs for therapeutic applications in cancer is also evidenced because they are so stable that they can be easily detected in serum of cancer patients, and it can be concluded that by paying attention to the significant role of Let7 in association with metastasis, we can say that it can be an appropriate candidate for curing breast cancer.
  • Keywords: Let7, cancer, MicroRNA, metastasis