Heat shock proteins in patients with type 2 diabetes

Heat shock proteins in patients with type 2 diabetes
Azadeh Teimury,^1,* Zohreh Zahraei,²
1. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran
Introduction: Heat shock proteins (HSP) are a large family of proteins that are expressed in response to various types of stresses. Many studies have confirmed the association of these proteins, especially the HSP70 family; with type 2 diabetes.
Methods: In this manuscript, based on studies and researches; at the first the structure and function of HSP70 was explained. The factors involved in diabetes (apoptosis, inflammatory, oxidative stress, insulin resistance, and defect in its signaling pathways) and their associations with HSPs were discussed. Then some explanations will be given about type 2 diabetes, especially its association with cancer diseases. HSP levels in patients with type 2 diabetes and its association with the duration of the disease are compared with healthy controls.
Results: The conserved structure of heat shock proteins plays an important role in their importance and that these types of chaperones could be targets for extensive studies in relation to various diseases. In this article, based on a review of various studies and researches, it has been proven that between the causes of type 2 diabetes such as inflammation, oxidative stress, insulin resistance or signaling defects, and the level of heat shock proteins, especially HSP70 There is an obvious link. In addition, the level of HSP70 chaperones is directly related to the duration of the disease.
Conclusion: Form various studies and researches, it will be concluded that the HSP70 levels are higher in patients with type 2 diabetes and in patients with longer duration of disease compared with healthy control.
Keywords: Heat shock proteins - HSP70- diabetes- Oxidative stress