Antibacterial activity of zinc oxide nanoparticles on Escherichia coli

Antibacterial activity of zinc oxide nanoparticles on Escherichia coli
Koroush Motaghinia,¹ Shohreh Nasiri poroj,^2,* Neda Zamani,³ Sorour Aalipanah,⁴ Parisa Khiabanirad,⁵ Mahdieh Ramezani,⁶
1. Department of medicinal chemistry, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
2. Department of Microbiology, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
3. Department of Microbiology, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
4. Department of Microbiology, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
5. Department of medicinal chemistry, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
6. Department of medicinal chemistry, Faculty of Life Sciences, Islamic Azad University, North Tehran Branch
Introduction: Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometres. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. The present study was aimed to explore the antibacterial effects of ZnO NPs on E.Coli O157: H7.
Methods: In this study, The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of nanoparticles of zinc oxide were determined using well assay method.
Results: According to the results of this study, the MIC values of ZnO nanoparticles for this bacterium were 4 mg/ml and the MBC values for Escherichia coli isolate were 8 and 4 mg/ml, respectively.
Conclusion: The present study showed that zinc oxide nanoparticles can be used as a deterrent against the pathogens of the materials and avoid contamination. Finally, the results obtained in this study suggest that the use of ZnO-NPs as an antibacterial agent in food systems can successfully inhibit some of the most dangerous and frequent foodborne pathogens.
Keywords: Nanoparticle, Zinc Oxide, Escherichia coli, Antibacterial