Vitamin-B6 Effect on Decreasing the Risk of Pancreatic Cancer

Vitamin-B6 Effect on Decreasing the Risk of Pancreatic Cancer
haniehbaghnavi@gmail.com,^1,* sarafana@varastegan.ac.ir,²
Introduction: Pancreatic cancer arises when cells in the pancreas begin to multiply out of control and form a mass. This tumor rarely occurs before the age of 40, and more than half of cases of pancreatic adenocarcinoma suffer over 70. Vitamin B6 is a B group essential vitamin which has been implicated in increasing or decreasing the expression of certain genes. Some of the important effects of vitamin B6 are transcription of glucocorticoids, gene expression of albumin mRNA, influence on expression of glycoprotein IIb by interacting with various transcription factors. As the result of this vitamin on expression of genes, we decided to review the effect of it on pancreatic cancer.
Methods: We conduct a comprehensive search in Medline and PubMed databases for trials, case-control and cohort studies.
Results: All the studies confirm that, Consumption of vitamin B6 in the higher quintiles reduced the risk of pancreatic cancer from 22% to 54% in different studies. The intervention in those taking vitamin B6 supplement could decrease the advantage of cancer by 42% and consumption with vitamin B6 + B9 together could decrease the cancer advantage by 76%. This vitamin may play a role in protecting DNA against oxidative damage and subsequent mutations and therefore can lower the risk of cancer.
Conclusion: Vitamin B6 intake could significantly reduce the risk of pancreatic cancer. The greatest effect of this intervention happen when vitamin B6 and B9 consumed together.
Keywords: pancreatic cancer, vitamin B6,vitamin B9