Circulating RNAs as promising diagnostic biomarkers for endometriosis

Circulating RNAs as promising diagnostic biomarkers for endometriosis
Sepideh Abdollahi,¹ Pantea Izadi,^2,*
1. Tehran university of medical sciences
2. Tehran university of medical sciences
Introduction: Endometriosis is one of the common gynecologic disorders at the reproductive age of women, which can lead to infertility and pelvic pain. The diagnosis of endometriosis remains invasive, thus a reliable non-invasive biomarker or panels of biomarkers are urgently needed. To this end, circulating RNAs including miRNAs and mRNAs have been studied as peripheral blood biomarkers in affected individuals. In this review, the latest results of these studies are provided, which suggest expanding studies concerning serum or plasma biomarkers for the diagnosis of endometriosis.
Methods: The research and review papers between 2000 and 2020 were selected from Pub Med, Scopus and Google scholar databases, aiming to evaluate the effectiveness of peripheral blood biomarkers for endometriosis.
Results: The studies showed that there was an aberrant expression of miRNAs in serum or plasma of patients with endometriosis. Also, they suggest a panel of five miRNAs, which can distinguish between women with endometriosis and control women. On the other hand, some results demonstrated altered expression of VEGF and Survivin genes as diagnostic significance for endometriosis.
Conclusion: Due to importance of miRNAs and mRNA as a non-invasive diagnostic biomarker in endometriosis, the expanding of studies concerning the expression of important genes, which are involved in the pathogenesis of endometriosis, in peripheral blood or evaluation panel of important altered expression of miRNAs and mRNAs may be useful to consider as biomarkers for detecting endometriosis non-invasively.
Keywords: endometriosis; blood; biomarker; mRNA; non-invasive; miRNA