• Study the affection of protein-based nanoparticles in cancer vaccine: A review
  • Mahtab Aghaee Jaghargh,1,* Elham Aminifar,2
    1. Student research committee, Islamic azad university, Mashhad Branch, Mashhad, Iran.
    2. Student research committee, Islamic azad university, Mashhad Branch, Mashhad, Iran.


  • Introduction: One of the concerns in medical science is the treatment of cancers. Statistical studies in Iran for cancer show that 167.1 per 100,000 males and 125.7 per 100,000 females have cancer. Almost one sixth of deaths are caused by cancer. Existing treatments have not been able to cure the disease completely, but nanotechnology in medicine may help to cure it. Due to the side effects of other previous treatments, such as chemotherapy, it is necessary to study the effects of nanoparticles in treatment of cancer. For this reason, previous studies have suggested using nanoparticles in cancer vaccine. Cancer vaccine stimulates the immune system to eradicate cancer cells. Cancer vaccines are used to treat existing cancers (therapeutic vaccines) or to prevent cancer (preventive vaccines). Therapeutic vaccines inhibit the growth of existing cancers, prevent the recurrence of treated cancers, or eradicate cancer cells that have not been eradicated by previous treatments. Preventive vaccines are designed to eradicate cancer-causing viruses and prevent viral infections. The aim of this review is to investigate about protein-based nanoparticles effects on cancer treatment with vaccine.
  • Methods: We checked the words Nanoparticles, Protein, Cancer vaccines in MESH and searched on PubMed, Cochrane, Iranmdex and SID database from 2008 to October 2019. We found 39 articles that 25 of them were excluded from the study by investigating the titles and 5 others by checking abstract; finally, 9 articles are included in our study.
  • Results: .
  • Conclusion: We conclude that, due to the important effects of protein-based nanoparticles on the cancer vaccine, a specific type of protein has not been suggested for cancer types. In studies, they use protein such as Mucin, ɣ-glutamic acid, E7, E2 and Tyrosinase for cure and prevent cancer or viruses such as Triple negative breast cancer, human papillomavirus (HPV) type 16 and melanoma. The effects of other proteins have not been investigated. It needs to be tested on human models and various types of cancers.
  • Keywords: Nanoparticles, Protein, Cancer vaccine