3rd International Congress on Biomedicine (ICB2019)
The association between serum levels of vitamin D and immunoglobulins in patients with urinary tract infection
The association between serum levels of vitamin D and immunoglobulins in patients with urinary tract infection
Leila Pirdel,1,*Manijeh Pirdel,2
1. Islamic Azad University, Ardabil Branch 2. Islamic Azad University, Astara Branch
Introduction: Vitamin D plays important roles in immune functions as its deficiency may be associated with increased risk of infectious diseases. We aimed to determine any association between serum levels of 25-hydroxy vitamin D and the components of humoral immunity in patients with urinary tract infection (UTI).
Methods: In this case-control study, 100 women (65 in the case group and 35 in the control group), who were between 18-60 years old, were studied. Serum 25(OH)D levels and immunoglobulins (IgG, IgM and IgA) were measured by ELISA. The measurement of serum complement C4 and C3 levels as well as the estimation of CH50 was performed by using immunodiffusion plates. The association between these components and 25(OH)D levels was also assessed.
Results: Serum 25(OH)D levels significantly decreased in patients compared to the control group. In the case group, about 27.7% of the subject had deficient levels (<10 ng/ml) of 25(OH)D and 38.4% of the subjects had insufficient levels (10 to 30 ng/ml). Sufficient levels of 25(OH)D (30 to 100 ng/ml) were found in 33.9% of the subjects. Although serum IgM levels as well as the complement component C4 and CH50 were not significantly different between the two groups which had no significant association with serum 25(OH)D levels, serum levels of IgG, IgA and C3 were significantly higher in patients than in the control group. Whereas serum 25(OH)D levels were positively associated with IgA and C3, serum IgG levels had a negative association with serum 25(OH)D.
Conclusion: The 25(OH)D status affects the modulation of host immune response to infection. It was found that the alteration of humoral immunity components is more or less consistent with 25(OH)D levels; however, given the prevalence of vitamin D deficiency, the importance of this condition in humoral immunity will be worth considering more closely.