3rd International Congress on Biomedicine (ICB2019)
Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration
Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration
Parisa Goodarzi ,1Sepideh Alavi-Moghadam,2Akram Tayanloo-Beik ,3Fereshteh Mohamadi-jahani ,4Khadijeh Falahzadeh ,5 Babak Arjmand,6,*
1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 4. Brain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran Iran 5. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran
Introduction: Wound healing is a complex process with a considerable burden on the healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Herein, in this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.
Methods: The authors have used the 106 papers extracted from databases PubMed, Scopus, and Web of Science to search around the effects of mesenchymal stem cells-derived exosomes in wound regeneration.
Results: Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to store, and stability in the body.
Conclusion: The advantages of exosomes make them as a novel approach in regenerative medicine without the limitations of cellular therapy.