Investigating the effects of origanum vulgare extract on biochemical parameters including uric acid, creatinine and urea in diabetic rats

Mojghan Mosayebzade,1,*



Sweet mellitus diabetes is classified as one of the metabolic disorders, which its characteristic property is to increase blood sugar because of mall functions in releasing insulin. chronically increasing blood sugar may cause long time damages and mall performances in several vital organs such as eye, kidneys, nervous system, heart, and blood vessels. sweet diabetes has been changed into a major hazard in global health, because of rapid population growth, old populations, spreading obesity, and lack of physical exercise. special attention is therefore necessary to prevent diabetes and its consequences. diabetes is the most substantial reason for kidney disorders in all over the world and it has various medical, social, and economic consequences. the aim of the present study is to investigate the effects of marzanjoush extract on diabetes nephropathy parameters including the level of creatinine, uric acid, and urea


42 field mousses from the race wistar were utilized in these experiments and categorized randomly into 6 groups; group, one was considered as the control non-diabetic group, group, two was diabetic control group, group, three was sheme and three remainder groups were treated with marzanjoush extract with respectively different concentrations of 200, 400, and 600 milligram per each kilogram of the samples weight. diabetic mousses were received the extract for three months and the blood samples were taken from all the groups at the end of each month. the investigation of creatinine, urea, and uric acid concentrations were performed using a spectrophotochemical techniques with biochemical kits


Marzanjoush herbal extract decreased considerably the level of creatinine, urea, and uric acid in blood samples of diabetic field mousses and this extract can be regarded as a potential drug for decreasing blood sugar with the minimum side effects.


The obtained results demonstrated that the level of the aforementioned chemical species in blood samples had significant increase and herbal extract has also decreased blood sugar in diabetic groups


Diabetes; urea; creatinine; uric acid; marzanjoush.