Adiponectin and diseases

Adeleh Dastres,1 Najmeh tehranian,2,*

Abstract

Introduction

Adipose tissue has been recognized not only as a reservoir of energy-rich molecules but also has an important endocrine organ producing cytokines called adipokines such as adiponectin which has several effects on the reproductive system that was discovered in 1995,adiponectin is 30-kda protein of 244 amino acids with at least to receptors,is almost exclusively produced by adipose tissue,it has several impacts such as insulin sensitizing, anti-inflammatory, anti-sclerotic, anti-apoptotic effect and it has an important role in normal function and health or disease of reproductive organ.

Methods

The design of the study is a literature review. we search google scholar, pubmed and science direct database from 2005 until 2018. identified studies that evaluated the adiponectin and disease

Results

Abnormal level of adiponectin level associated with obesity, type 2 diabetes mellitus, stroke, metabolic syndrome, hypertension, dyslipidemia, cardiovascular disease, myocardial infarction, non-alcoholic fatty liver disease, kidney and pulmonary disease, endometrial hyperplasia, pco, endometriosis, recurrent miscarriage. it has the protective effect against cancer by enhancing of caspase and apoptosis process of tumoral cells and antiproliferative effects, the decrease of adiponectin can be a risk factor for endometrial hyperplasia and endometrial cancer, ovarian cancer, pco, recurrent miscarriage and endometriosis.

Conclusion

Adipose tissue has been recognized not only as a reservoir of energy-rich molecules but also has an important endocrine organ producing cytokines called adipokines such as adiponectin,it has several impact such as insulin sensitizing,anti-inflammatory, anti-sclerotic, anti-apoptotic effect and it has important role in normal function and health or disease of reproductive organ, abnormal level of adiponectin level associated with several complication such as obesity , type 2 diabetes mellitus ,stroke ,metabolic syndrome,hypertension,dyslipidemia, cardiovascular disease, obesity-related cancers such as colorectal cancer, postmenopausal breast cancer ,ovary and endometrial cancer, therefore decrease of adiponectin can be a risk factor for endometrial hyperplasia and endometrial cancer, ovarian cancer, pco, recurrent miscarriage and endometriosis, it seam adiponectin upregulation may be a strategy for improving adiponectin related disease, adiponectin can be a promising therapeutic approach for this condition.

Keywords

adiponectin-ovarian-miscarriage-endometriosis-therapeutic