Evaluation of the efficacy of organic nanoparticles on pseudomonas aeruginosa

Mojgan Oshaghi,1,* Niloufar rashidi,2 Parisa roshani asl,3

1. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Introduction

Pseudomonas aeruginosa is one of the most important opportunistic pathogens contributes to a large number of healthcare-associated infections. the treatment of infections caused by this pathogen is difficult because of the inherent and acquired resistance to the most effective antimicrobial agents. the continued evolution of drug resistance has disallowed many routinely used antibiotics. nanotechnology, proposes a promising platform for addressing this challenge. unique properties and multiple bactericidal mechanisms of nanomaterials, make them more effective than conventional drugs. nowadays, the development of organic nanomaterials for biomedical practices has increased. the focus of this paper is to present a review of the potential applications of organic nanoparticles (nps) in control of p. aeruginosa and also describes their distinctive features and method of function.

Methods

The information of this article was collected by searching the keywords related to the subject on the electronic databases and surveying different scientific articles published in reliable online journals.

Results

Organic nps can load molecules either by conjugation on the surface or in the core, or by physical encapsulation, which make them attractive systems for drug delivery and biomedical applications. lipid-based nps (liposomes, solid lipid nps, nanoemulsions), polymeric nps and dendrimers are examples of organic nps that their ability to eradication of p. aeruginosa has proven by several research groups. have been reported that these nps could have antimicrobial and antibiofilm effects against p. aeruginosa. lots of studies demonstrated that encapsulated antibiotics into these organic nps, enhances the microbial susceptibility and antimicrobial activity of antibiotics against p. aeruginosa clinical isolates. the bioavailability, biocompatibility, safety of encapsulated drug, localization in particular organs, increased period of action and reduced the side effects are some benefits of organic nps that introduce them as the hopeful means of antibiotics carriage. since their mechanism of action seems to be the disruption of bacterial cell membranes, they would not cause to the creation of resistant strains.

Conclusion

According to the studies, organic nps have great potential for preventing and treating p. aeruginosa infections. although the biocompatibility of nps is generally determined by in vitro research, their safety and cytotoxicity must be more evaluated. however, the studies demonstrates the tendency to overcome the obstacles and realize the promises of nanomaterials for medical applications.

Keywords

Pseudomonas aeruginosa, organic nanoparticles, antimicrobial, antibiofilm