Role of angiogenesis signaling and mechanism of treatment in glioblastoma

Mohammad amin Dehghani,1,* Saleh rasras,2 Maryam shirani,3 Fatemeh dehghani,4 Seyyed hossein hassanpour,5 Khashayar alikarami,6

1. Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Department of Neurosurgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Department of Genetics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6. School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Introduction

Purpose: this study aimed to investigate the role rol of angiogenesis signaling and mechanism of treatment in glioblastoma

Methods

Methods: we extracted all relevant studies of angiogenesis signaling and mechanism of treatment in glioblastoma by searching electronic databases pubmed, embase, web of science from inception to feb 28,2017.

Results

Results: high‐grade gliomas are aggressive vascular tumors, and as in the majority of cancer types, blood vessels in advanced lesions are extremely abnormal. angiogenesis plays a significant role in gbm pathobiology largely because glioblastoma multiforme (gbm) poses a significant metabolic demand for oxygen delivery and waste removal to maintain its high rates of cell proliferation and metabolism. gbm also expresses high levels of vegf. vegf-vegfr pathway had advanced to a most promising therapeutic target for the treatment of gbm. the recent findings have reported that fgfr-tacc fusions are clonal events in clinical gbm specimens that manifest the strong tumor initiating capacity. an increase in anti-angiogenic therapies (aats) and increase in neutrophil infiltration are associated with poor survival in patients with glioblastomas, glioma grade and acquisition of resistance to anti-vegf therapy. anti-vegf-a therapy has become part of standard post-surgical treatment for gbm, which has a temporary beneficial effects and does not effectively extend patient overall survival. epidermal growth factor receptor ( egfr) gene rearrangements and expression of their aberrant protein products are present in glioblastoma multiforme.

Conclusion

C onclusion: the amplification of egfr gene is the most frequent genetic alteration associated with gbm. the mechanism of angiogenesis signaling and aats offer us the opportunity to increase our understanding of this extremely complex pathway and potential for the treatment of glioblastoma.

Keywords

Glioblastoma; angiogenesis; aats; vegf; fgfr; fgfr; sdf-1.