Study on the effect of human microbiome on cancer

Fatemeh Yousef saber,1 Afrouzossadat hosseini-abari,2,*

1. University of Isfahan
2. University of Isfahan



Cancer is leading cause of morbidity and mortality all around the world. it’s a multifaceted condition that a cell begins dividing in an irregular manner due to various factors including a micro-environment rich in inflammatory cells, growth factor, dna damage and activated stroma which induce cell proliferation and inhibit apoptosis among other factors. specific microbes are linked to almost every cancer such as colon, pancreatic, gastric, lung, liver and also prostate, whether by displaying unique characteristics in their ability to regulate changes in their host niche that can increased risk of cancers or by displaying the exactly opposite function to eliminate pathogens and limit the progression of cancers.


The literature is systematically reviewed, based on clinical documents, related books, scientific articles and also reliable sites including northwestern university knight lab .


Studies indicates that human microbiome which includes the collective genome of bacteria, archaea, fungi, protists and viruses, living in and on the human body, have tumor-suppressive properties. diet, age, antibiotics consumption, genetics and physiology are the reasons of wide microbial diversity. microbiota can also be rearranged for improving cancer treatment specially in personalized medicine.


The significant function of microbiota is protection against colonization by pathogens. unlike pathogenic microbes which cause or develop different cancers, human microbiome has a potential role in a tumor suppression or as a treatment.


Cancer, human microbiome