Biomedicine Congress - Biology Congress - Medicine Congress

Association of a genetic variant in cdkn2a/b, rs1333049, with increased risk of cervical cancer

Negin Behboudi,¹ Motahareh heidarian,² Amirhosein jafarian,³ Nooshin babapour,⁴ Amir avan,⁵ Malihe hasanzadeh,^6,*

1. Department of Biochemistry and Biophysics, Mashhad Branch, Islamic Azad University
2. Department of Biochemistry, Payam-e Noor University of Mashhad
3. Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences
4. Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sci.
5. Metabolic syndrome Research center, Mashhad University of Medical Sciences
6. Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sci.

Abstract

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Introduction

Cervical cancer (cc) is among the most common diagnosed cancer. several genetic variants have been identified in the 9p21 region with the risk of developing several cancers. thus, here we investigated the association of rs1333049 in chromosome 9p21 in patients with cervical cancer.

Methods

Dnas were extracted from 221 subjects with/without cc. genotyping was performed by taqman real-time pcr. logistic regression was used to explore the association between cc risk and genotypes, while the significant prognostic variables in the univariate analysis were included in multivariate analyses.

Results

Our data showed patients with cc was associated with the increased risk of developing cervical cancer (e.g., or in recessive genetic model: 3.2, 95%ci:1.7-6.2, p<0.001).

Conclusion

We demonstrated the association of a genetic variant in cdkn2b gene with cervical cancer, indicating further investigation in a multi-center setting to assess the value of marker as a risk stratification marker in cervical cancer.

Keywords

Cervical cancer, rs1333049, cdkn2b.