1. Islamic Azad university medical branch of tehran 2. Islamic Azad university medical branch of tehran 3. Mashhad university of medical sciences 4. Mashhad university of medical sciences 5. Mashhad university of medical sciences 6. Mashhad university of medical sciences
Abstract
Introduction
Esophageal cancer (ec) is among the leading causes of cancer death in the developing countries. it has been reported that smoking, alcohol consumption, hot tea drinking poor oral hygiene, low socioeconomic status, and genetic variants are related to a higher risk of esophageal squamous cell carcinoma (escc). particularly atp-binding cassette superfamily (abc) is involved in transferring drugs, detoxification, regulation of protein synthesis, and cell resistance. rs2032582, which is a tri-allelic missense variant on abcb1 gene, has reported being associated with drug resistance. here we explored the association of abcb1 rs2032582 with escc for the first time in 314 subjects, with and without escc.
Methods
Dna was extracted from escc patients and genotyped by taqman real-time pcr. kaplan meier was applied to analyze overall survival and progression-free survival followed by log-rank to compare the data. logistic regression was utilized to assess the relationship between escc risk and genotypes
Results
Our data showed that escc patients had a higher frequency of a t/a (tt/ta/aa) genotype for rs2032582 than individuals with gg-genotype. there were no associations between patients bmi and genotypic frequencies. furthermore, patients with tt/ta/aa genotype had poor disease-free survival (p.value=0.016) in comparison with gg genotype.
Conclusion
We demonstrated the significant association of abcb1 rs2032582 with the prognosis of escc patients.
