1. Shahid Beheshti University of Medical Sciences 2. Shahid Beheshti University of Medical Sciences 3. Shahid Beheshti University of Medical Sciences
Abstract
Introduction
Advanced glycation end products (ages) are a heterogeneous group of macromolecules that are formed by the non-enzymatic glycation of proteins, lipids, and nucleic acids. ages have been related to increased risk of a number of chronic diseases. the aim of present study is to assess the relationship between dietary consumption of ages and risk of obesity and central obesity.
Methods
This study was conducted within the framework of the tehran lipid and glucose study (tlgs) on 4245 subjects who participated in its fifth phase. dietary data were collected using a validated semi-quantitative food frequency questionnaire (ffq). participants’ characteristics, anthropometric measures and blood samples were also obtained by trained staff. all statistical analysis was conducted using spss (version 20; chicago, il), and p values < 0.05 were considered significant.
Results
Our results show that abdominal obesity was increased with higher intakes of dietary ages, an association, which remained significant after adjustment for potential confounders (or=1.56 and95% ci, 1.16 to 2.84). the relationship between abdominal obesity and dietary ages (dages) intake was found to be independent of energy and macronutrient intake. we also found a relationship between consumption of dages and a few anthropometric measurements, such that a significant positive correlation was observed between bmi, wc, bai and higher quartiles of dages intake, with the correlation being stronger for bai (or=2.21).
Conclusion
Our study emphasizes that higher intakes of dages does increase the chance of abdominal obesity, and dages might be a link between modern diets and obesity.
Keywords
General obesity, abdominal obesity, advanced glycation end products
