The association of the h19 rs217727 polymorphism and preeclampsia
Mahdiyeh Haratisadegh,
1,* Saeedeh salimi,
2
1. Department of genetics, Marvdasht Branch , Islamic Azad University, Marvdasht , Iran
2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Abstract
Introduction
Pre-eclampsia is a pregnancy specific disorder; which is defined as pregnancy-induced hypertension and proteinuria. h19 is an imprinted gene transcribing a long noncoding rna and previously has been reported to be involved in some diseases. however, the association between the h19 polymorphisms and pre-eclampsia (pe) susceptibility has remained elusive. the aim of this study was to evaluate the association between three h19 snp (rs217727) and the risk of pe.
Methods
The present case control study comprised 193 pe women and 201 controls. the h19 rs217727 polymorphism was genotyped with pcr-rflp (polymerase chain reaction–restriction fragment length polymorphism) method.
Results
The frequency of the h19 rs217727t allele was significantly higher in pe women (p= p<0.0001). the h19 rs217727 polymorphism was associated with higher pe susceptibility in the co-dominant (or=12.1, 95% ci=5.96-24.54, p<0.0001 for ct genotype and or=29.69, 95% ci=12.93-68.17, p<0.0001 for tt genotype), dominant (or=15.14, 95% ci=7.56-30.32, p= p<0.0001), recessive (or=4.53, 95% ci=2.58-7.97, p=<0.0001) and over-dominant (or=2.03, 95% ci=1.36-3.04, p=0.0006) models.
Conclusion
In conclusion, the present study found the association of h19 rs217727t polymorphism and pe susceptibility.
Keywords
Gene, h19, polymorphism, preeclampsia
