Gene bookmarking, a way to detect, predict and control molecular processes

Parniyan Ghari,1,* Maryam naderi soorki,2

1. Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2. Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran



Gene bookmarking is a mechanism of epigenetic memory for gene expression transmission programs, during cell division. the mechanisms that involved in epigenetic memory, help the expression memory transition of some genes through successive divisions and also lead to preservation of the cell's phenotype. current therapeutic strategies are aiming to target the main trends of histone modifications, which are required to control the uncontrolled expression of genes.


Many improvements have been applied in the component detection, likewise the organization of regulatory complexes in chromosomal gene loci; such as high resolution microscopy techniques, invivo genomic occupancy assay and also genome-wide expression analysis, which allowed us to introduce a whole new level of epigenetic visions for gene bookmarking, besides histone marks and dna methylation.


Dna methylation and histone modifications, both have the main role in the epigenetic transmission of the transcriptional memory, furthermore small ncrna molecules and also durability of gene expression regulatory mechanism during division, both are important epigenetic factors in controlling gene expression in parent cell and resulting cells.


As a conclusion to all this, gene bookmarking can provide epigenetic and remarkable signs that can be used to detect, predict and also to control many of molecular events in an effective way, including disease, like leukemia and osteosarcoma. depending on recent studies, the cooperation between transcriptional adjustment machine and some target genes in mitosis chromosomes can be introduced as a new epigenetic mechanism. any possible changes of these trends can lead to the development of diseases, including a variety of cancers.


Bookmarking, epigenetic memory, histone codes, ncrna, disease prediction and control