Effects of rosmarinic acid on oxidative stress and total antioxidant capacity in vivo study

Atefeh sadat Ghoreishian,1,* Mehran miroliaei,2

1. Cell, Developmental and Molecular Biology Division, Department of Biology, Faculty of Science, University of Isfahan, Is



Diabetic disease is characterized by chronic hyperglycaemia. numerous studies have shown that in diabetes mellitus, there exists an accumulation of advanced glycated end-products (ages), increased oxidative stress, enhanced angiotensin ii levels and activation of inflammatory mechanisms, which play a critical role in the development of diabetes and diabetic complications. the adverse effects of most of those factors have often been linked to the generation of reactive oxygen species (ros). it has been proposed that oxidative stress (a disturbance in the balance between the production of reactive oxygen species, free radicals, and antioxidant defenses) plays a crucial role in the progression and severity of diabetic disease. the aim of this study was to investigate the anti-oxidant effect of rosmarinic acid (ra), a phenolic compound that commonly found in plants of lamiaceae family that has various biological properties such as anti-bacterial and anti-inflammatory, on diabetic animal models.


In this step investigated the efficacy of ra administration on diabetic animal models (rat). the animals received ra and then ros and diabetes was evaluated by some tests such as abts, dpph, ferric chloride and etc.


Experimental data showed that the use of ra could prevented and retarded the development of diabetes and complication of it in the animal models.


Ra because of its anti-oxidant property could inhibition or slow the progression of diabetes and complication of it by neutralize ros and increase antioxidant defense.


Diabetes, stress oxidative, reactive oxygen species, rosmarinic acid, anti-oxidant