Direct or indirect contact with pesticides and toxins leads to some biochemical changes, including increasing the production of active oxygen species and oxidative stress in humans. increasing malondialdehyde(mda) and lipid peroxidation level and reducing the total antioxidant capacity (tac)level are its symptoms. therefore, the aim of this study evaluated the effect of toxins on lipid profiles, tac and mda in sprayer men.
Methods
This practical study was conducted to evaluate the serum level of lipid profile,tac and mda among sprayer workers in east azarbaijan. target population was 90 people and were divided into two treatment groups (45 man) with six-month spraying experience and the control group (45man) without any spraying experience. blood samples were enrolled from all subjects in fasting status and lipid profiles were measured by pars azmoon kit and hitachi 911. the mdalevel as a marker of plasma lipid peroxidation was measured by a thiobarbituric acid kit(abcam, usa).serum tac was measured by using ferric reducing ability of sreum (frap) assay kit(abcam, usa). the results were compared using spss version 19 and independent sample t-test method (p<0.05).
Results
Serum lipid profile showed a non- significant increase in the treatment group compared to the control group, while malondialdehyde level in the treatment group showed a significant increase and total antioxidant capacity decreased significantly (respectively p=0.03, p<0.0001).
Conclusion
The results of this study showed that exposure to toxins has not a significant effect on serum lipid profiles but increases the oxidative stress and increased malondialdehyde in these individuals.
