Correlation between oral health status and salivary total antioxidant capacity in type 2 diabetes mellitus among iranian adults

Hourolein Arab,1,*

1. MSc of Clinical Biochemistry, Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sc



Diabetes mellitus is a chronic metabolic disease leading to several complications. among these, dental caries are considered as one of the major complication of diabetes mellitus. patients with type 2 diabetes mellitus (t2dm) demonstrate evidence of oxidant–antioxidant imbalances in their biological fluids such as saliva. imbalance between oxidative stress and antioxidants in saliva plays a major role in initiation of dental caries. the aim of this study was to evaluate correlation between oral health status and salivary total antioxidant capacity (tac) in t2dm among diabetic iranian adults.


50 t2dm adult patients (20 female and 30 male) with age range of 21 -69 years were selected. oral examination to assess the dental caries experience was carried out using decayed, missing and filled teeth (dmft) index. unstimulated whole saliva specimens were collected at the morning. tac of saliva was evaluated by spectrophotometric assay. statistical analysis was performed using pearson’s correlation test, by spss 18.


With increasing dmft scores, tac of saliva decreased correspondingly .there was significant negative correlation between tac level and dmft scores(r = -0.398, p < 0.006).


Tac of saliva could be a marker for dental caries activity among t2dm.


Antioxidants, dental caries, diabetes, saliva