Chronic wounds resemble the wounds arising with skin squamous cell carcinoma (scc). since they are cancerous, they should be treated using novel bioactive wound dressing instead of biopsy and related procedure for detection. using a noninvasive method is necessary for early detection and proper treatment. the aim of this study is to investigate gpr55 overexpression by quantitative real-time pcr as a biomarker for early detection of skin squamous cell carcinoma (scc).
In a clinical trial, 10 patients were randomly assigned to treatment and were compared to 10 healthy people in control group. overexpression of gpr55 gene was evaluated by quantitative real-time pcr in both groups
The expression of gpr55 gene was significantly higher in treatment group compared to the control group.
The results of the study suggest that the overexpression of gpr55 can be utilized as a biomarker for detection of skin scc.