Effect of salvia hydrangea extract on memory improvement and alzheimer apoptosis reduction: a systematic review

Fatemeh Kaviani,1 Fatemeh aliakbari,2,*

1. Student Research Committee,Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Ph.D. Nursing, Faculty Member of School of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord,



Alzheimer disease is a neurogenic disease caused by progressive disorders of the central nervous system, which has a learning and memory system, and also causes a opoptosis in different parts of the central nervous system. this disease is the most common cause of dementia. studies have shown that euclidean extract has a strong potential in preventing alzheimer disease. therefore, the aim of this paper is to investigate the effect of salvia hydrangea extract on the improvement of memory and decrease of alzheimer apoptosis.


The present study is a review article by using the systematic search of articles in internal validated databases (sid, magiran, iramedex) with keywords (salvia hydrangea,memory improvement, alzheimer) and foreign credentials (scopus, web science, pubmed) with the keywords (salvia hydrangea, memory improvement, alzheimer) from 2009 to 2017.


Out of 45 articles, 26 articles in farsi and 19 articles in english have been published. of the retrieved results, 43 articles eligible for this review were reviewed and categorized. in 50% of the papers, salvia has been considered as having a potent potential for inhibiting beta-amyloid neuronal degeneration, as a neurotransmitter compound, in preventing and treating neurodegenerative diseases, including alzheimer, as well. chromatography studies also showed that phenols such as gentamic acid, chlorogenic acid, vanillic acid, caffeine and synergic acid are present in the salvia hydrangea plant, which increases the antioxidant activity and increases the creb phosphorylation.


According to the results of the studies, the erythne plant has a significant role in improving memory and reducing apoptosis in the hippocampus and the foreskin cortex, but more accurate studies on salvia hydrangea and its constituents can be a good alternative to clinical studies and drug development for the treatment of alzheimer disease.


Salvia hydrangea, memory improvement, alzheimer