The effect of mucoadhesive gel containing satureja hortensis extract of 1% on severity of chemotherapy-induced mucositis pain in children: a double-blind clinical trial study

Tahereh Alvandnezhad,1,* mohammad arshadi bostanabad,2 Amirataollah hiradfar,3 Asghar mohammadpoorasl,4 Yousef javadzadeh,5 Bagher khalvati,6

1. Master of pediatric Nursing, Tabriz University of Medical Sciences, Tabriz, Iran
2. PhD, Assistant Professor, Department of Nursing, School of Nursing and Midwifery, Tabriz University of Medical Sciences
3. Assistant Professor of pediatric hematology and oncology, Department of pediatrics, Tabriz University of Medical Science
4. PhD, Assistant Professor, Department of Health services management research cente, Tabriz University of Medical Science
5. PhD, Professor of Pharmaceutics, Department Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran
6. MSc in Computer Science, IT Department, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz,

Abstract


Introduction

One of the symptoms of mucositis caused by chemotherapy is pain. mucositis management is initiated by assessment of oral hygiene and management of pain. many uses have been mentioned for satureja hortensis in traditional medicine. the study was carried out with the aim of determining the effect of satureja hortensis extract mucoadhesive gel of 1% on severity of mucositis-induced pain in children under chemotherapy.

Methods

This double–blind clinical trial study was carried out on 60 children who were affected by mucositis following chemotherapy in 2016. the samples were randomly assigned into two groups of intervention and control. the intervention group applied satureja hortensis extract gel of 1% and the control group applied the placebo gel twice daily for 5 days after the onset of mucositis along with routine treatment. oral mucosa was evaluated daily. also, the oucher pain tools and a demographic questionnaire were used. the data was analyzed using the chi-square test, t-test and analysis of variance (anova) for repeated measures.

Results

The obtained data showed that the two groups had statistical difference in terms of the severity of the pain relief during the time, and pain severity reduced from 3.5±2.1 to 0.0 ± 0.0 in intervention group and 3.1 ± 1.8 to 0.4 ± 1.0 in control group in fifth day (p <0.001).

Conclusion

The study showed that the extract of satureja hortensis is effective in healing mucositis induced pain and can be used as a new treatment method in relieving reducing mucositis pain.

Keywords

Satureja hortensis, mucositis, children, chemotherapy, pain