1. the Department of toxicology, Shahreza Branch. Islamic Azad University, Esfahan, Iran
Bleomycin is an effective antibiotic with anti-tumor activity that has a minimum toxic effect on hematopoietic tissues and the immune system and can be widely used with the other chemotherapeutic agents. lung injury is the most devastating side-effect of the anti-cancer drug bleomycin which often progresses to pulmonary fibrosis, that its prevalence depending on the risk factors is reported as 2-4% in patients under treatment and its mortality is reported in 1-5% of the patients. the objective of the present study is to evaluate antioxidant and anti-inflammatory effects of atorvastatin and the extract of olibanum on bleomycin-induced pulmonary fibrosis.
Male wistar rats were randomly divided into four groups. the positive control group received bleomycin sulfate (1 u/100 g bw) intra-tracheal. in the negative control group, normal saline and propylene glycol (pg) and in the treatment group, 120 mg/kg hydro-alcoholic extract of olibanum were injected intraperitoneally a week before bleomycin administration and treatment was continued until 14 days afterwards.the levels of malondialdehyde (mda) and hydroxyproline (oh-proline) were detect.
The levels of malondialdehyde (mda) and hydroxyproline (oh-proline) were evaluated in the lung which showed 138 and 90 percent increases in bleomycin group compared to the control group, respectively (p<0.05). an increase in the above factors in the treatment group have been equal to 34.92 and 22.05 percent (p<0.05)
Histological studies showed reduced fibrosis in the treatment group. according to the obtained results, it can be said that the hydro-alcoholic extract of olibanum could control the pulmonary fibrosis and play an effective role in its reduction.