Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries

Azita Yahyavi,1,* Masoud parish2,2

1. MSc.Master of Toxicology, Clinical Research Development Unit , Shohada Hospital, Tabriz University of Medical Sciences
2. Scientific Board Member of Anesthesia, Department of Anesthesia, Shohada Hospital, Tabriz University of Medical Science

Abstract


Introduction

Many patients undergo orthopedic surgeries due to trauma. postoperative pain is high and severe and many non steroidal anti inflammatory drugs are used for analgesia other than opioids. but their use is limited for fear of drug induced complications specially anti platelet effects. the aim of this study was the evaluation of the non-steroidal anti inflammatory drugs toxicity on platelets function on patients,undergoing orthopedic patients.

Methods

370 patients were enrolled in this prospective descriptive corss-sectional study. the study group included 185 patients under treatment with non-steroidal anti inflammatory drugs , and the patients with no drug therapy were in control group, hematologic variables including hemoglobin, hematocrit , coagulation test ,volume of bleeding and platelets were recorded in two groups.

Results

In this study there was no significant difference between two groups in regard to age, sex, tobacco use, coagulation tests and hemorrhage during surgery. the high volume bleeding (control group) and number (study group) was seen. in study group the most aspirin use was noted. the platelets were decreased postoperatively 6.2%in study and 7.33% in control group which the least was related to ketorolac and the maximum to naproxen. the postoperative hemoglobin. hematocrit and platelet reduction was significant compared to the preoperative value.

Conclusion

the results of this study showed that using low-dose non steroidal anti inflammatory drug in patients undergoing orthopedic surgeries has no toxic effect on platelets and can be use safely.

Keywords

Nonsteroidal anti-inflammatory drugs, toxicity, orthopedic surgery, platelets.