application of gold nanoparticles as drug carriers: a systematic review

Saba Dadpour,1,*

1. Islamic Azad University of Pharmaceutical Sciences

Abstract


Introduction

Most drugs are limited by their pharmacodynamics properties as well as cytotoxicity and aggregation due to poor solubility, nonspecific delivery, and in vivo short circulating half-lives. drug delivery system can serve to improve poor solubility, limited stability, biodistributions and pharmacokinetics of drugs. moreover, this system can be functionalized with ligands to target specific tissues and cell types. gold nanoparticles have excellent stability and biocompatibility, tailorable shapes and sizes, an easily functionalized surface, high drug-loading capacity, and low toxicity. these nanoparticles have been used to target delivery of chemotherapeutic agents, antibiotics and other drugs. this study focuses essentially on the functionalization strategies and potential applications of gold nanoparticles in the field of drug delivery. we review current progress with gold nanoparticles in the drug-delivery field, present their unique properties in drug-delivery applications and suggest future work in this area.

Methods

This article is a kind of systematic review in which the information was collected by searching on the internet, limited in english language and without time limitations. we used data sources such as medline, pubmed and cochrane with special key words such as gold nanoparticles, drug delivery, drug carriers and nanotechnology.

Results

There are numerous recent reports on the applications of gold nanoparticles in the delivery of anti tumor and anti bacterial drugs, showing enhanced efficacy of treatment. gold nanoparticles can be functionalized with active targeting ligands to increase their specific binding to the desired drug-delivery systems.

Conclusion

In this article we have reviewed recent advances on the applications of drug delivery by gold nanoparticles . owing to their inherent features, these nanoparticles have proven to be highly attractive and stable for drug delivery.

Keywords

Gold nanoparticles, drug delivery, nanotechnology, drug carrier