Evaluation of the antinociceptive effect of alcoholic extract of walnut leaf (rigia juglans): systematic review

Marjan Baradaran,1,* Fatemeh aliakbari,2 Fatemeh kaviani,3

1. Bachelor of Science in nursing. Student research committee. Shahrekord University of medical sciences. shahrekord. Iran
2. Faculty Member of School of Nursing and Midwifery, Shahrekord University of Medical Sciences. . shahrekord. Iran
3. Bachelor of Science in nursing. Student research committee. Shahrekord University of medical sciences. shahrekord. Iran

Abstract


Introduction

Abstract: pain is an experience that often results from tissue damage and is related to severity of the injury. some pain in the long time impairs the mental and psychological effects on the patient. for this reason, humans are looking for a way to eliminate or reduce pain. due to the side effects and the various adverse effects of analgesia, medicinal herbs are known as new analgesic agents; therefore, the purpose of this article, was toreview the effect of alcoholic extract of walnut leaves (rigia juglans).

Methods

The search method: this study is a review study by systematic search of articles in persian validated databases (sid, magiran, iramedex) with keywords (analgesic, alcoholic extract, walnut leaves) and international credentials (scopus, web science, pubmed with the keywords (pain intensity, alcoholic extract, rigia juglans) from 2009 to 2017.

Results

Results: out of 40 articles, 15 articles in farsi and 25 articles in english have been published. of the retrieved results, 20 articles eligible for this review were reviewed and categorized. it has been shown in 50% of the papers that walnut leaves have very effective analgesic effects. also, studies have shown that walnut leaf extract significantly reduces the pain in the acute phase, even when administered with morphine, the analgesic effect of morphine increases in the acute phase.

Conclusion

Conclusion: according to the results of studies that has been reviewed about alcoholic extract of walnut leaves, it has a significant role in pain relief; however, few studies have been carried out in this field. therefore, more rct studies on the extract of walnut leaf and its constituents can be a good alternative in clinical studies and drug making. reduce pain.

Keywords

Antinociceptive, alcoholic extract, walnut leaves