hajar najafi,1negar farajzadeh dehkordi,2sepideh sarlak,3fatemeh soltanimoghadam,4atefe esmailpour,5amin hajhosseini,6,*
1. Master of community Health Nursing, Faculty of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran. 2. Student of Community Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 3. Student of Master Intensive Care Nursing, Shahid Sadughi University of Medical Sciences, Isfahan, Iran 4. Department of Biology, Science and Arts University, Yazd, Iran 5. Student Research Committee, Mazandaran University of Medical Sciences, Mazandaran, Iran. 6. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran.
Introduction: Graphene-based nanomaterials with unique morphological properties are very useful for sensing applications. Highly sensitive electrochemical and biosensors are of great importance not only for biomedical applications and clinical diagnostics, but also for environmental protection. Therefore, this study aimed to determine the effect of a graphene-based biosensor on the detection of cholesterol.
Methods: In the forthcoming systematic study, the required data were collected using keywords and citing valid databases such as: Scopus PubMed, Google Scholar and ProQuest. The statistical population of the study includes all studies conducted up to 2022 in the field of biosensors to detect graphene-based cholesterol, a total of 16 articles were analyzed.
Results: After searching, 28 articles were found, and finally 12 articles were included in the study. Based on the results, biosensors can be classified according to the conversion mechanism: Biosensors, optical detection, thermal detection, ion sensitivity, electrochemical, and Malhotra sensors. Graphene-based sensors have shown good sensitivity and selectivity for the detection of glucose, cholesterol, hemoglobin, H2O2, small biomolecules, DNA, heavy metal ions, and toxic gaseous molecules. The use of graphene can avoid problems associated with NP and CNT metal alloys.
Conclusion: The unique properties of graphene-based materials (fast electron transfer, high thermal conductivity, excellent mechanical flexibility, good biocompatibility, high electrochemical activity, and easy surface functionalization) make them applicable for electrochemical analyte identification and biosensors with excellent results. Cholesterol biosensors are considered an important tool for the clinical analysis of numerous diseases such as cardiovascular diseases. Therefore, there is a need to develop the most effective and accurate device for effective cholesterol monitoring.