negar zamani alavijeh,1,*
1. Department of biology,Higher institute Naghsh-jahan, Isfahan, Iran
Introduction: One of the top 10 most prevalent malignancies in the world is oral cancer which has a poor prognosis, a delayed clinical diagnosis, no known biomarkers for the illness, and expensive treatment options. Because each patient presents the treating doctors with a different set of issues, the care of oral cancer is a multidisciplinary endeavor that affects both survival and quality of life. This research aims to examine the potential impact of microRNA on gene expression.
Methods: The GEO2R software in the GEO dataset was used to analyze the study of the expression of genes related to all types of cancer on the dataset GSE31056. The DAVID database's most differentially expressed genes were examined to determine which gene was most responsible for the occurrence of oral cancer. Additionally, the miRWalk database was used to find the microRNAs linked to this gene. Identification of the microRNAs influencing oral cancer was made possible by the Human microRNA Disease Database (HMDD).
Results: The plasminogen activator, urokinase (PLAU) gene was shown to be the most beneficial gene in treating oral cancer, according to the findings. Regarding the miRWalk database's identification of hsa-let-7e-5p and hsa-let-7b-5p as PLAU-related microRNAs. Additionally, it was found by using the HMDD database that hsa-let-7b may be a microRNA involved in the development of oral cancer by miRNA-induced gene upregulation.
Conclusion: Understanding the mechanisms affecting the target gene's expression may allow us to alter the course of the disease, and identifying the implicated microRNAs as markers may assist in disease management. On the function of microRNAs related to the PLAU gene, more thorough research is required.