Introduction: Colon adenocarcinoma (COAD) is one of the most common types of gastrointestinal malignancies, and studying molecular mechanisms can be an important step in the prevention process. cadherin3(CDH3), a gene encoding P-cadherin, which is one of the main components of adherens junctions and is closely related to the development and development of various types of tumors(1).One of the non-specific clinical symptoms of this cancer is very fast progression and metachronous metastasis, which is the cause of death with colon adenocarcinoma (COAD)(2).
Methods: First, gene expression data of COAD patients (GSE50114) were obtained from NCBI gene.
And then of (GEO) expressed genes were analyzed by GEO2R
And using the Encori database, DIY expression, survival, and co-expression charts were checked, the Enrichr database was used to analyze the signaling pathway. And the signaling pathway was checked in KEGG and Reactome database.Then, from the String data, we were able to check the interaction between genes, and with Mirwalk, miR was selected and the relationship between miR expression in COAD disease was checked in Encori LncBase, lncRResearch obtained the list of lncRna and its accuracy was checked in the gene card website. And in lnc base, lnc related to miRna was investigated And finally ceRNA was predicted.
Results: CDH3 was found to be a significantly up-regulated gene in COAD tissue compared to normal human tissues. In addition, COAD patients with higher levels of CDH3 in their tumor tissues survive longer compared to patients with moderate to low levels (3). CDH3 gene regulates tight junction & estrogen signaling pathways & adherens junction ٫It is associated between miR-1250-5p and LAMP-a51 And because this lcnc gene It regulates the CDH3 gene and regulates the signaling pathway on COAD disease, and expression disorder causes COAD disease. and LAMP-a51 expression disorder causes COAD dieses disorder .
Conclusion: miR-1250-5p LAMP-AA1 and LAMP-a51 regulate the dieses state by regulating CDH3 expression.