The correlation between IL-6 and IL-10 expression in symptomatic children with HHV-6 infection

The correlation between IL-6 and IL-10 expression in symptomatic children with HHV-6 infection
Hassan Karami,¹ Farhad Rezaei,^2,*
1. Virology Department, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Virology Department, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Introduction: Human Herpes Virus-6 is a cause of common childhood exanthemas with symptoms such as high fever and skin rashes. Given the clinical manifestations of the virus disease, the immune responses especially the correlation between the expressive inflammatory (i.e. IL-6) and anti-inflammatory (i.e. IL-10) cytokines may play a key role in the immunopathogenesis of the disease. We designed this study to investigate the correlation between IL-6 and IL-10 in symptomatic children with HHV-6 infection.
Methods: For the present study, we randomly used 25 PCR-confirmed throat specimens for HHV-6 collected from children aged <5 years old with at least fever and rash as two main clinical pictures. Real-time PCR was performed on all these 25 specimens using specific primers. Finally, the results were analyzed by PRISM 2008 software.
Results: Despite the absence of the same study, we found a positive significant correlation between the expression of IL-6 and IL-10 in HHV-6-infected children in the symptomatic phase of illness (P-value: <0.05).
Conclusion: Our study indicated that cytokines and their relationship can implicate in the pathogenesis of acute HHV-6 infection in the early stages of life.
Keywords: Correlation, IL-6, IL-10, Children, HHV-6