Evaluation the toxicity of Quercus infectoria extract on some biochemical and hematological parameter in mice

Evaluation the toxicity of Quercus infectoria extract on some biochemical and hematological parameter in mice
Jeyran Beyranvand,^1,* Ali valibeik,² Negar Naderi,³ Amir Morady,⁴ alireza Moayyedkazemi,⁵ Mohamad-nabi Moradi,⁶
1. Student Research Committee, Lorestan University of Medical Sciences, Khoramabad, Iran
2. Student research committee, Lorestan University of Medical Sciences. Khoramabad, Iran.
3. Student research committee, Lorestan University of Medical Sciences. Khoramabad, Iran.
4. Student research committee, Lorestan University of Medical Sciences. Khoramabad, Iran.
5. Department of Internal Medicine, Lorestan University of Medical Science. Khoramabad, Iran.
6. Department of Clinical Laboratory Sciences. School of Allied Medicine, Lorestan University of Medical Science. Khoramabad, Iran
Introduction: Today, plants and their components have an important role in the treatment of diseases. Therefore, due to the increasing use of plant compounds, each plant product should be evaluated in terms of toxicological properties before being used in pharmaceutical form. This research was designed to assess the acute and subacute toxicity of Quercus infectoria extract on hematological and some serum biochemical parameters in mice.
Methods: Plant materials were collected from villages in Lorestan province, west of Iran. To determine the acute toxicity, four groups of mice (each group includes 6 mice) received different doses (0.5, 1, 2, and 4 mg/kg) of Q.infectoria extract orally. Sub-acute toxicity was performed by examining the biochemical and hematological parameters of forty treated mice after consuming different doses (150, 300 and 600 mg/kg) of Q.infectoria extract, orally for 14 days.
Results: The acute toxicity (LD50) tests of the oral administration of Q. infectoria extract, showed an estimated value of LD50 of mg/kg and the maximum nonfatal dose of mg/kg.
Conclusion: The findings demonstrated that orally administration of Q. infectoria at the doses of 150, 300 and 600 mg/kg for 14 days had no significant toxicity on the serum hematological and biochemical parameters.
Keywords: Quercus infectoria, Mice, Acute toxicity, Sub-acute toxicity