• Metagenomics Studies in Diagnosis and Treatment of Prostate Cancer
  • Ali Zarei,1,* Hossein Javid,2
    1. Iranian Academic Center for Education, Culture & Research (ACECR)-Fars Branch Institute for Human Genetics Research.
    2. Iranian Academic Center for Education, Culture & Research (ACECR)-Fars Branch Institute for Human Genetics Research.


  • Introduction: The mutation occurred in prostate cell genes lead to abnormal prostate proliferation and cancer. Prostate cancer is one of the most common cancers among men, and its prevalence in Iran is increasing with the age of men. About 16% of the world’s cancers caused by microbes that live in the human body. Impaired population balance of symbiosis microbes that live in the human reproductive ecosystem is associated with the development of prostate cancer. In this review, we intend to interrogate the role of metagenomics studies in the diagnosis and treatment of prostate cancer.
  • Methods: literature review
  • Results: The microbial imbalance in the genital tract of men may affect prostate health. Based on Next Generation Sequencing-generated data, proteobacteria phylum (Escherichia, Pseudomonas, and Acidovorax genera) most frequently has been detected in a prostate cancer sample, which induces mutation in the prostate cells and causes cancer.
  • Conclusion: With the advent of metagenomics science, the genome sequences of the microbiota of the human body became known. Therefore, it was possible to identify a higher range of microbiome changes in prostate cancer tissue through the Next Generation Technique, and this will have good consequences in personalized medicine. Many kinds of researches are underway to investigate and identify novel microbes in prostate cancer tissue.
  • Keywords: Prostate Cancer-Metagenomics-Next Generation Sequencing-Microbiome