• The effect of aerobic exercise and ginseng on sexual hormones in obese rats
  • mojde shahba,1,* mandana ghplami,2 hossien abed natanzi,3 farshad ghazalian,4 iman rad,5 Ehsan Salarkia,6
    1. Science and Research Branch, Islamic Azad University
    2. Science and Research Branch, Islamic Azad University
    3. Science and Research Branch, Islamic Azad University
    4. Science and Research Branch, Islamic Azad University
    5. Cell Therapy and Regenerative Medicine Comprehensive Center Kerman University of Medical Sciences Kerman, Iran


  • Introduction: Infertility and its individual and social problems are one of the most important issues for young couples. About half of all infertility is in men. Aerobic and sexual activity have the potential to improve spermatogenesis and reduce the side effects of obesity. Therefore, in this study, the combined effect of sexing supplementation with aerobic exercise on the fertility of obese mice was investigated.
  • Methods: In this study, 32 male Wistar mice weighing about 200 to 250 g and average age of 8 weeks were divided into 4 groups of eight. The high-fat diet (45% of calories in fat) was used to induce obesity in mice. The mice trained for five days (1 hour) every week for eight weeks. Simultaneously with exercise, gensing extract was given to the target groups by gavage. After the last exercise session, the animals were anesthetized and their blood was immediately poured into a tube containing EDTA. Also, after measuring body weight, testicles and prostate, samples were taken from the fetuses and some sperm parameters were examined.
  • Results: The results showed that the weight changes of mice as well as sperm concentration, percentage of normal sperm shape, percentage of motile sperm, adult sperm percentage of rats in all three experimental groups including training group, gensing group and gensing group with difference training It is significant compared to the control group (P <0.001). On the other hand, the results of weight change showed that in none of the studied groups, testicular and prostate weight was not significantly different from the control group (p <0.05). Examination of the results of testosterone changes showed that there was a significant increase compared to the control group in both sexing and sexing groups with exercise (P <0.001). This increase was not significantly different in the exercise group and the control group. The results of counting testicular tissue cell lines showed that there was no significant difference between the groups in any of the spermatogonia, spermatocytes and Leydig and Sertoli cell lines (p <05). Significant differences were observed only in spermatogonia cells in the gensing group with exercise and Leydig cells in the gensing group (P <0.05). The results of testicular spermatogenesis indices showed no significant difference between the groups in any of the TDI, SI and RI indices (p <05). Significant differences were observed only in TDI index in the gensing group with exercise and RI index in the gensing group (P <0.05).
  • Conclusion: The results of this study showed that aerobic exercise and gensing consumption in both groups improves spermatogenesis indices in the studied groups. In the group of both training and consumption of gensing extract, the improvement of these indicators has been more effective.
  • Keywords: Infertility, Aerobic exercise, Gensing, Obesity