• Therapeutic effects of young plasma injection on the brain of the elderly
  • Negar Yeganeh Khorasani,1,* Fatemeh Alvandi,2 Valareza Alizadeh,3
    1. Pharmacy Student of Mashhad University of Medical Sciences, Mashhad, Iran.
    2. Pharmacy Student of Mashhad University of Medical Sciences, Mashhad, Iran.
    3. Medical Student of Islamic Azad University, Mashhad branch, Mashhad, Iran.


  • Introduction: Aging is the main cause of the most common human diseases. From about a decade ago to today, the Parabiosis method has become a useful method for studying the effect of an animal's age on its health. In this method, a young mouse shares its circulatory system with an old mouse. Sometime later, experiments showed that the blood of young mice in old mice had a rejuvenating effect, while the blood of older mice in young mice had a bad effect. New vascular networks have shown improvement in neuroinflammation as well as various age-related brain diseases, such as Alzheimer's (AD), Parkinson's (PD). Recently, significant efforts have been made to elucidate the positive effects of young plasma injection on the structure and neural function of the brain in mice and humans. And examine its limitations to determine prospects in this area. In this review we aim to investigate the Therapeutic effects of young plasma injection on the brain of the elderly.
  • Methods: In this review, we include an article that discusses young blood plasma on Brain tissue rejuvenation. All articles were published between 2016_2020 and have ethical considerations. We searched PubMed and Google Scholar search engine with acute keywords “young blood plasma”, “Alzheimer's disease”, “brain rejuvenation”. Initially, 63 articles were found using this method. Then We excluded 38 articles from the study by considering abstract and used 25 articles in this review.
  • Results: In 10 articles, the effect of plasma injection of young mice on AD model mice was shown, which showed that injection of plasma of young mice on AD mice can restore the levels of synaptic and neural proteins, thus short-term memory, learning, spatial memory. And the hippocampus of older mice has a positive effect. A study was conducted to evaluate the safety and efficacy of fresh frozen plasma injection of young people (yFFP) in people with mild to moderate Alzheimer's (AD), which showed that yFFP is safe and improves mild to moderate AD. In 7 articles, the effect of plasma injection of young mice on the brain tissue of old mice was studied, and their results showed that plasma injection of young mice had a rejuvenating effect on the neural tissue of old mice. In one study, the effect of plasma injection in young people on the treatment of advanced supranuclear palsy (PSPRS) was investigated. The results of the study showed that injection of young plasma did not affect slowing the progression of the disease. In the other study, the effect of bone marrow transplantation from young to old mice was investigated. The results showed that bone marrow transplantation in young mice improves learning ability and memory in older mice by stabilizing synaptic connections and reducing microglial activation in the hippocampus. In 4 articles, the factors in the plasma of young people and their rejuvenating effects on tissues, especially brain nerve tissue in the elderly were studied. Another study was performed to determine the safety, tolerability, and possibility of plasma injection in people with Parkinson's disease (PD) and showed that the injection of young frozen plasma in a small group with PD is safe and has therapeutic effects.
  • Conclusion: So far, studies have been conducted to elucidate the positive effects of youth plasma injection on brain function in mice and humans, which could be the first step in the development of drugs to treat diseases such as Alzheimer's and Parkinson's. However, the researches have been accompanied by limitations, such as the small sample size and short follow-up time. The results of larger clinical trials controlled with a double-blind placebo can make the results of these studies reliable if they have similar results. Further investigation is also needed for a dose, pharmacokinetic, and pharmacodynamic analysis.
  • Keywords: Alzheimer's disease, young blood plasma, brain rejuvenation, Parabiosis