• Overview in the use of nanosystem to Target Cancer Metastasis
  • Mahdi Nasiri,1,*
    1. Young Researchers and Elite club, Central Tehran Branch, Islamic Azad University, Tehran, Iran


  • Introduction: The systemic spread of malignant cells from a primary site, a procedure denominate metastasis indicate a global challenge in cancer treatment and cause of cancer- relevanted fatality that accounting for 90% of cancer deaths. The precipitate development of cancer research has naked new mechanistic network and pathways that promote metastasis
  • Methods: As a result, a major number of antitumor factors have been expand for their antimetastatic efficacy. Notwithstanding their cytotoxic effects on tumor cells and antitumor activities in preclinical research in vivo, only a few have shown powerful antimetastatic activities in clinical trials. On the other hand rapid growth in nanotechnology toward the development of nanomedicine agents holds massive promise to improve therapeutic approaches against cancer
  • Results: They have been analyzed for different clinical applications, such as drug carriers, gene delivery to tumors, and contrast agents in imaging. A wide range of nanomaterials based on organic, inorganic, lipid, or glycan compounds, as well as on synthetic polymers has been utilized for the development and improvement of new cancer and antimetastatic therapeutics
  • Conclusion: This review highlights the research on the applications of nanoparticles in the treatment of metastatic cancer and antimetastatic strategies, particularly on the possible effect on cell stabilization, growth inhibition, conditional interaction with adhesion molecules to develop nanotechnology-based tools for treating metastatic.
  • Keywords: Nanoparticles, antimetastatic strategies, nanomedicine , malignant cells